The long-term impact of folic acid in pregnancy on offspring DNA methylation: follow-up of the Aberdeen Folic Acid Supplementation Trial (AFAST) | Zendy

Rebecca C. Richmond | Zendy; Gemma C. Sharp | Zendy; Georgia Herbert | Zendy; Charlotte Atkinson | Zendy; Caroline M. Taylor | Zendy; Siladitya Bhattacharya | Zendy; Doris M. Campbell | Zendy; Marion H. Hall | Zendy; Nabila Kazmi | Zendy; Tom R. Gaunt | Zendy; Wendy L. McArdle | Zendy; Susan M. Ring | Zendy; George Davey Smith | Zendy; Andy Ness | Zendy; Caroline L. Relton | Zendy

Open Access

The long-term impact of folic acid in pregnancy on offspring DNA methylation: follow-up of the Aberdeen Folic Acid Supplementation Trial (AFAST)

Author(s) -

Rebecca C. Richmond,

Gemma C. Sharp,

Georgia Herbert,

Charlotte Atkinson,

Caroline M. Taylor,

Siladitya Bhattacharya,

Doris M. Campbell,

Marion H. Hall,

Nabila Kazmi,

Tom R. Gaunt,

Wendy L. McArdle,

Susan M. Ring,

George Davey Smith,

Andy Ness,

Caroline L. Relton

Publication year - 2018

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyy032

Subject(s) - folic acid , folic acid supplementation , offspring , pregnancy , dna methylation , medicine , methylation , term (time) , folic acid antagonists , homocysteine , obstetrics , physiology , dna , biology , genetics , gene , gene expression , physics , quantum mechanics

It has been proposed that maternal folic-acid supplement use may alter the DNA-methylation patterns of the offspring during the in-utero period, which could influence development and later-life health outcomes. Evidence from human studies suggests a role for prenatal folate levels in influencing DNA methylation in early life, but this has not been extended to consider persistent effects into adulthood.

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