Confounding by ill health in the observed association between BMI and mortality: evidence from the HUNT Study using offspring BMI as an instrument | Zendy

David Carslake | Zendy; George Davey Smith | Zendy; David Gunnell | Zendy; Neil M Davies | Zendy; Tom Ivar Lund Nilsen | Zendy; Pål Romundstad | Zendy

Open Access

Confounding by ill health in the observed association between BMI and mortality: evidence from the HUNT Study using offspring BMI as an instrument

Author(s) -

David Carslake,

George Davey Smith,

David Gunnell,

Neil M Davies,

Tom Ivar Lund Nilsen,

Pål Romundstad

Publication year - 2017

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyx246

Subject(s) - body mass index , medicine , hazard ratio , overweight , offspring , confounding , demography , confidence interval , proportional hazards model , nurses' health study , pregnancy , biology , sociology , genetics

The observational association between mortality and body mass index (BMI) is U-shaped, leading to highly publicized suggestions that moderate overweight is beneficial to health. However, it is unclear whether elevated mortality is caused by low BMI or if the association is confounded, for example by concurrent ill health.

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