Maternal alcohol use during pregnancy and offspring attention-deficit hyperactivity disorder (ADHD): a prospective sibling control study | Zendy

Espen Moen Eilertsen | Zendy; Line C. Gjerde | Zendy; Ted ReichbornKjennerud | Zendy; Ragnhild Ørstavik | Zendy; Gun Peggy Knudsen | Zendy; Camilla Stoltenberg | Zendy; Nikolai Olavi Czajkowski | Zendy; Espen Røysamb | Zendy; Kenneth S. Kendler | Zendy; Eivind Ystrøm | Zendy

Open Access

Maternal alcohol use during pregnancy and offspring attention-deficit hyperactivity disorder (ADHD): a prospective sibling control study

Author(s) -

Espen Moen Eilertsen,

Line C. Gjerde,

Ted ReichbornKjennerud,

Ragnhild Ørstavik,

Gun Peggy Knudsen,

Camilla Stoltenberg,

Nikolai Olavi Czajkowski,

Espen Røysamb,

Kenneth S. Kendler,

Eivind Ystrøm

Publication year - 2017

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyx067

Subject(s) - offspring , pregnancy , attention deficit hyperactivity disorder , medicine , confounding , alcohol use disorder , confidence interval , cohort study , prospective cohort study , sibling , psychiatry , psychology , alcohol , developmental psychology , biochemistry , chemistry , genetics , biology

Maternal alcohol use during pregnancy has repeatedly been associated with development of attention-deficit hyperactivity disorder (ADHD) in the offspring. It is, however not known whether this reflects a direct casual intra-uterine effect or a non-causal relationship due to confounding. We used three different approaches to control for measured and unmeasured confounding: statistical adjustment for covariates, negative control comparison against maternal pre-pregnancy alcohol use, and comparison among differentially exposed siblings.

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