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Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique Fernando Pires Hartwig*, Neil Martin Davies, Gibran Hemani and George Davey Smith Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil, Medical Research Council Integrative Epidemiology Unit at the University of Bristol and School of Social and Community Medicine, University of Bristol, Bristol, UK