Obesity-induced hypoadiponectinaemia: the opposite influences of central and peripheral fat compartments | Zendy

Maria Carolina Borges | Zendy; Isabel Oliveira | Zendy; Deise Farias Freitas | Zendy; Bernardo Lessa Horta | Zendy; Ken K. Ong | Zendy; Denise P. Gigante | Zendy; Aluísio J. D. Barros | Zendy

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Obesity-induced hypoadiponectinaemia: the opposite influences of central and peripheral fat compartments

Author(s) -

Maria Carolina Borges,

Isabel Oliveira,

Deise Farias Freitas,

Bernardo Lessa Horta,

Ken K. Ong,

Denise P. Gigante,

Aluísio J. D. Barros

Publication year - 2017

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyx022

Subject(s) - adiponectin , abdominal obesity , medicine , waist , adipose tissue , endocrinology , mendelian randomization , intra abdominal fat , obesity , confidence interval , insulin resistance , visceral fat , biology , biochemistry , genetic variants , genotype , gene

The substantial reduction in adiponectin concentration among obese individuals seems to depend on fat distribution and is a marker of metabolic and adipose tissue dysfunction. We aimed to: (i) address whether abdominal fat from different compartments (visceral, deep subcutaneous abdominal and superficial subcutaneous abdominal) and gluteofemoral fat are independently associated with blood adiponectin concentration; and (ii) investigate whether abdominal (proxied by waist circumference) and gluteofemoral fat (proxied by hip circumference) accumulation causally determine blood adiponectin concentration.

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