Pleiotropy-robust Mendelian randomization | Zendy

Hans van Kippersluis | Zendy; Cornelius A. Rietveld | Zendy

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Pleiotropy-robust Mendelian randomization

Author(s) -

Hans van Kippersluis,

Cornelius A. Rietveld

Publication year - 2017

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyx002

Subject(s) - mendelian randomization , pleiotropy , randomization , genetics , medicine , mendelian inheritance , biology , bioinformatics , clinical trial , genetic variants , gene , phenotype , genotype

The potential of Mendelian randomization studies is rapidly expanding due to: (i) the growing power of genome-wide association study (GWAS) meta-analyses to detect genetic variants associated with several exposures; and (ii) the increasing availability of these genetic variants in large-scale surveys. However, without a proper biological understanding of the pleiotropic working of genetic variants, a fundamental assumption of Mendelian randomization (the exclusion restriction) can always be contested.

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