Paracetamol use during pregnancy and attention and executive function in offspring at age 5 years | Zendy

Zeyan Liew | Zendy; Cathrine Carlsen Bach | Zendy; Robert F. Asarnow | Zendy; Beate Ritz | Zendy; Jørn Olsen | Zendy

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Paracetamol use during pregnancy and attention and executive function in offspring at age 5 years

Author(s) -

Zeyan Liew,

Cathrine Carlsen Bach,

Robert F. Asarnow,

Beate Ritz,

Jørn Olsen

Publication year - 2016

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyw296

Subject(s) - pregnancy , medicine , confidence interval , odds ratio , confounding , executive functions , offspring , executive dysfunction , pediatrics , cognition , demography , psychiatry , neuropsychology , genetics , biology , sociology

We studied 1491 mothers and children enrolled in the Danish National Birth Cohort (DNBC; 1996-2002). Prenatal paracetamol use was prospectively recorded in three telephone interviews. Trained psychologists assessed child's attention function using the Test of Everyday Attention for Children at Five (TEACh-5). Parents and preschool teachers completed Behaviour Rating Inventory of Executive Function (BRIEF) to assess executive functions. We estimated the differences of composite mean outcome scores, and odds ratios (OR) for subnormal attention or executive function (defined as 1 standard deviation below the mean), adjusting for maternal IQ, maternal mental health, indications for paracetamol use and other potential confounders.

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