Promoter CpG island methylation in ion transport mechanisms and associated dietary intakes jointly influence the risk of clear-cell renal cell cancer | Zendy

Ivette A.G. Deckers | Zendy; Ma van Engeland | Zendy; Piet A. van den Brandt | Zendy; Leander Van Neste | Zendy; Patricia M.M.B. Soetekouw | Zendy; Maureen J.B. Aarts | Zendy; Marcella Baldewijns | Zendy; András Keszei | Zendy; Leo J. Schouten | Zendy

Open Access

Promoter CpG island methylation in ion transport mechanisms and associated dietary intakes jointly influence the risk of clear-cell renal cell cancer

Author(s) -

Ivette A.G. Deckers,

Ma van Engeland,

Piet A. van den Brandt,

Leander Van Neste,

Patricia M.M.B. Soetekouw,

Maureen J.B. Aarts,

Marcella Baldewijns,

András Keszei,

Leo J. Schouten

Publication year - 2016

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyw266

Subject(s) - methylation , dna methylation , cpg site , hazard ratio , medicine , cancer , confidence interval , endocrinology , biology , oncology , cancer research , gene , genetics , gene expression

Sodium intake, but not potassium or fluid intake, has been associated with higher renal cell cancer (RCC) risk. However, risk factors may differ by molecular subtypes of the tumour. In renal physiology, electrolyte and water homeostasis is facilitated by ion transport mechanisms (ITM). Aberrant regulation of ITM genes, for example by promoter CpG island methylation, may modify associations between sodium, potassium and fluid intake and RCC risk.

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