Non-specific effects of BCG vaccination on morbidity among children in Greenland: a population-based cohort study | Zendy

Simon Haahr | Zendy; Sascha Wilk Michelsen | Zendy; Mikael Andersson | Zendy; Karen Bjørn-Mortensen | Zendy; Bolette Søborg | Zendy; Jan Wohlfahrt | Zendy; Mads Melbye | Zendy; Anders Koch | Zendy

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Non-specific effects of BCG vaccination on morbidity among children in Greenland: a population-based cohort study

Author(s) -

Simon Haahr,

Sascha Wilk Michelsen,

Mikael Andersson,

Karen Bjørn-Mortensen,

Bolette Søborg,

Jan Wohlfahrt,

Mads Melbye,

Anders Koch

Publication year - 2016

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyw244

Subject(s) - medicine , vaccination , poisson regression , tuberculosis , pediatrics , rate ratio , confidence interval , epidemiology , cohort study , cohort , retrospective cohort study , infectious disease (medical specialty) , bcg vaccine , incidence (geometry) , population , immunology , disease , environmental health , physics , pathology , optics

The potential non-specific effects of BCG (Bacillus Calmette-Guérin) vaccination, with reported reduction of infectious disease morbidity among vaccinated children, in addition to the protective effect against tuberculosis (TB), are highly debated. In Greenland, BCG vaccination was introduced in 1955, but temporarily discontinued from 1991 to 1996 due to nationwide policy changes. Using the transient vaccination stop, we aimed to investigate possible non-specific effects of BCG vaccination by measuring nation-wide hospitalization rates due to infectious diseases other than TB among vaccinated and unvaccinated children.

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