Distance to health services modifies the effect of an 11-valent pneumococcal vaccine on pneumonia risk among children less than 2 years of age in Bohol, Philippines
Author(s) -
Elisabeth Dowling Root,
Marilla Lucero,
Hanohynek,
Rebecca W. Stubbs,
Veronica Tallo,
Socorro Lupisan,
Diozele Sanvictores,
Leilani T Nillos,
Eric A. F. Simões
Publication year - 2016
Publication title -
international journal of epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.406
H-Index - 208
eISSN - 1464-3685
pISSN - 0300-5771
DOI - 10.1093/ije/dyw217
Subject(s) - medicine , vaccination , pneumonia , placebo , hazard ratio , confidence interval , vaccine efficacy , randomized controlled trial , pediatrics , environmental health , immunology , alternative medicine , pathology
Both vaccine trials and surveillance studies typically use passive surveillance systems to monitor study outcomes, which may lead to under-reporting of study outcomes in areas with poor access to care. This detection bias can have an adverse effect on conventional estimates of pneumonia risk derived from vaccine trials.
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