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Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study
Author(s) -
JueSheng Ong,
Gabriel Cuéllar-Partida,
Yi Lu,
Peter A. Fasching,
Alexander Hein,
Stefanie Burghaus,
Matthias W. Beckmann,
Diether Lambrechts,
Els Van Nieuwenhuysen,
Ignace Vergote,
Adriaan Vanderstichele,
Jennifer A. Doherty,
Mary Anne Rossing,
Jenny ChangClaude,
Ursula Eilber,
Anja Rudolph,
Shan WangGohrke,
Marc T. Goodman,
Natalia Bogdanova,
Thilo Dörk,
Matthias Dürst,
Peter Hillemanns,
Ingo B. Runnebaum,
Natalia Antonenkova,
Ralf Bützow,
Arto Leminen,
Heli Nevanlinna,
Liisa M. Pelttari,
Robert P. Edwards,
Joseph L. Kelley,
Francesmary Modugno,
Kirsten B. Moysich,
Roberta B. Ness,
Rikki A. Cannioto,
Estrid Høgdall,
Claus Høgdall,
Allan Jensen,
Graham G. Giles,
Fiona Bruinsma,
Susanne K. Kjær,
Michelle A.T. Hildebrandt,
Dong Liang,
Karen H. Lu,
Xifeng Wu,
Maria Bisogna,
Fanny Dao,
Douglas A. Levine,
Daniel W. Cramer,
Kathryn L. Terry,
Shelley S. Tworoger,
Meir J. Stampfer,
Stacey A. Missmer,
Line Bjørge,
Helga B. Salvesen,
Reidun Kristin Kopperud,
Katharina Bischof,
Katja K.H. Aben,
Lambertus A. Kiemeney,
Leon F.A.G. Massuger,
Angela BrooksWilson,
Sara H. Olson,
Valerie McGuire,
Joseph H. Rothstein,
Weiva Sieh,
Alice S. Whittemore,
Linda S. Cook,
Nhu D. Le,
C. Blake Gilks,
Jacek Gronwald,
Anna Jakubowska,
Jan Lubiński,
Tomasz Kluz,
Honglin Song,
Jonathan P. Tyrer,
Nicolas Wentzensen,
Louise A. Brinton,
Britton Trabert,
Jolanta Lissowska,
Esther M. John,
Steven A. Narod,
Catherine Phelan,
Hoda AntonCulver,
Argyrios Ziogas,
Diana Eccles,
Ian Campbell,
Simon A. Gayther,
Aleksandra GentryMaharaj,
Usha Me,
Susan J. Ramus,
Anna H. Wu,
Agnieszka DansonkaMieszkowska,
Jolanta Kupryjańczyk,
Agnieszka Timorek,
Lukasz M. Szafron,
Julie M. Cunningham,
Brooke L. Fridley,
Stacey J. Winham,
Elisa V. Bandera,
Elizabeth M. Poole,
Terry K. Morgan,
Harvey A. Risch,
Ellen L. Goode,
Joellen M. Schildkraut,
Celeste Leigh Pearce,
Andrew Berchuck,
Paul D.P. Pharoah,
Georgia ChenevixTrench,
Puya Gharahkhani,
Rachel Ε. Neale,
Penelope M. Webb,
Stuart MacGregor
Publication year - 2016
Publication title -
international journal of epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.406
H-Index - 208
eISSN - 1464-3685
pISSN - 0300-5771
DOI - 10.1093/ije/dyw207
Subject(s) - mendelian randomization , medicine , ovarian cancer , oncology , randomization , association (psychology) , cancer , gynecology , genetics , randomized controlled trial , biology , gene , genotype , genetic variants , psychology , psychotherapist
In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findings. A potential limitation of observational studies is inadequate control of confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate the association between single nucleotide polymorphisms (SNPs) associated with circulating 25-hydroxyvitamin D [25(OH)D] concentration and risk of ovarian cancer.

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