Random Survival Forest in practice: a method for modelling complex metabolomics data in time to event analysis
Author(s) -
Stefan Dietrich,
Anna Floegel,
Martina Troll,
Tilman Kühn,
Wolfgang Rathmann,
Annette Peters,
Disorn Sookthai,
Martin von Bergen�,
Rudolf Kaaks,
Jerzy Adamski,
Cornelia Prehn,
Heiner Boeing,
Matthias B. Schulze,
Thomas Illig,
Tobias Pischon,
Sven Knüppel,
Rui WangSattler,
Dagmar Drogan
Publication year - 2016
Publication title -
international journal of epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.406
H-Index - 208
eISSN - 1464-3685
pISSN - 0300-5771
DOI - 10.1093/ije/dyw145
Subject(s) - proportional hazards model , european prospective investigation into cancer and nutrition , regression , random forest , regression analysis , multicollinearity , feature selection , statistics , medicine , prospective cohort study , computer science , oncology , data mining , mathematics , machine learning
The application of metabolomics in prospective cohort studies is statistically challenging. Given the importance of appropriate statistical methods for selection of disease-associated metabolites in highly correlated complex data, we combined random survival forest (RSF) with an automated backward elimination procedure that addresses such issues.
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