Software Application Profile: RVPedigree: a suite of family-based rare variant association tests for normally and non-normally distributed quantitative traits | Zendy

Karim Oualkacha | Zendy; Lajmi LakhalChaieb | Zendy; Celia M.T. Greenwood | Zendy

Open Access

Software Application Profile: RVPedigree: a suite of family-based rare variant association tests for normally and non-normally distributed quantitative traits

Author(s) -

Karim Oualkacha,

Lajmi LakhalChaieb,

Celia M.T. Greenwood

Publication year - 2016

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyw047

Subject(s) - genome wide association study , pedigree chart , suite , computer science , genetic association , software , quantitative trait locus , population , computational biology , biology , data mining , genetics , medicine , single nucleotide polymorphism , genotype , environmental health , archaeology , gene , programming language , history

RVPedigree (Rare Variant association tests in Pedigrees) implements a suite of programs facilitating genome-wide analysis of association between a quantitative trait and autosomal region-based genetic variation. The main features here are the ability to appropriately test for association of rare variants with non-normally distributed quantitative traits, and also to appropriately adjust for related individuals, either from families or from population structure and cryptic relatedness.

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