Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas | Zendy

Zahra Montazeri | Zendy; Evropi Τheodoratou | Zendy; Christine Nyiraneza | Zendy; Maria Timofeeva | Zendy; Wanjing Chen | Zendy; Victoria Svinti | Zendy; Shanya Sivakumaran | Zendy; Gillian Gresham | Zendy; Laura Cubitt | Zendy; Luis G. CarvajalCarmona | Zendy; Monica M. Bertagnolli | Zendy; Ann G. Zauber | Zendy; Ian Tomlinson | Zendy; Susan M. Farrington | Zendy; Malcolm G. Dunlop | Zendy; Harry Campbell | Zendy; Julian Little | Zendy

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Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas

Author(s) -

Zahra Montazeri,

Evropi Τheodoratou,

Christine Nyiraneza,

Maria Timofeeva,

Wanjing Chen,

Victoria Svinti,

Shanya Sivakumaran,

Gillian Gresham,

Laura Cubitt,

Luis G. CarvajalCarmona,

Monica M. Bertagnolli,

Ann G. Zauber,

Ian Tomlinson,

Susan M. Farrington,

Malcolm G. Dunlop,

Harry Campbell,

Julian Little

Publication year - 2015

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyv185

Subject(s) - meta analysis , genetic association , single nucleotide polymorphism , genome wide association study , genetics , methylenetetrahydrofolate reductase , penetrance , statistical power , biology , publication bias , allele , bioinformatics , genotype , medicine , gene , statistics , mathematics , phenotype

Low penetrance genetic variants, primarily single nucleotide polymorphisms, have substantial influence on colorectal cancer (CRC) susceptibility. Most CRCs develop from colorectal adenomas (CRA). Here we report the first comprehensive field synopsis that catalogues all genetic association studies on CRA, with a parallel online database [http://www.chs.med.ed.ac.uk/CRAgene/].

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