Methods for sample size determination in cluster randomized trials | Zendy

Clare Rutterford | Zendy; Andrew Copas | Zendy; Sandra Eldridge | Zendy

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Methods for sample size determination in cluster randomized trials

Author(s) -

Clare Rutterford,

Andrew Copas,

Sandra Eldridge

Publication year - 2015

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyv113

Subject(s) - sample size determination , crts , randomized controlled trial , statistics , computer science , sample (material) , cluster randomised controlled trial , covariate , cluster (spacecraft) , restricted randomization , research design , randomization , range (aeronautics) , clinical study design , mathematics , medicine , clinical trial , engineering , programming language , chemistry , computer graphics (images) , surgery , chromatography , pathology , aerospace engineering

The use of cluster randomized trials (CRTs) is increasing, along with the variety in their design and analysis. The simplest approach for their sample size calculation is to calculate the sample size assuming individual randomization and inflate this by a design effect to account for randomization by cluster. The assumptions of a simple design effect may not always be met; alternative or more complicated approaches are required.

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