Milk intake is not associated with ischaemic heart disease in observational or Mendelian randomization analyses in 98 529 Danish adults | Zendy

Helle K M Bergholdt | Zendy; Børge G. Nordestgaard | Zendy; Anette Varbo | Zendy; Christina Ellervik | Zendy

Open Access

Milk intake is not associated with ischaemic heart disease in observational or Mendelian randomization analyses in 98 529 Danish adults

Author(s) -

Helle K M Bergholdt,

Børge G. Nordestgaard,

Anette Varbo,

Christina Ellervik

Publication year - 2015

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyv109

Subject(s) - mendelian randomization , lactase , medicine , population , interquartile range , observational study , myocardial infarction , confidence interval , hazard ratio , demography , genotype , biology , environmental health , genetics , food science , lactose , genetic variants , sociology , gene

Observationally, reports on the association between milk intake and risk of ischaemic heart disease (IHD) and myocardial infarction (MI) have produced conflicting results; and no previous large-scale study using the lactase persistent/non-persistent LCT-13910 C/T genotype as a largely unconfounded proxy for milk intake free of reverse causation has been conducted. We tested the hypothesis that milk intake observationally and genetically through the LCT-13910 C/T genotype is associated with risk of IHD and MI in a Mendelian randomization design.

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