Mendelian randomization study of height and risk of colorectal cancer
Author(s) -
Aaron P. Thrift,
Jian Gong,
U. Peters,
Jenny ChangClaude,
Anja Rudolph,
Martha L. Slattery,
Andrew T. Chan,
Tõnu Esko,
Andrew R. Wood,
Jian Yang,
S. Vedantam,
S. Gustafsson,
Tune H. Pers,
J. A. Baron,
Stéphane Bézieau,
Sébastien Küry,
Shuji Ogino,
Sonja I. Berndt,
Graham Casey,
Robert W. Haile,
Mengmeng Du,
Tabitha A. Harrison,
M. Thornquist,
David Duggan,
Loı̈c Le Marchand,
Mathieu Lemire,
N. M. Lindor,
Daniela Seminara,
Mingyang Song,
Steven Thibodeau,
Michelle Cotterchio,
Aung Ko Win,
Mark A. Jenkins,
John L. Hopper,
Cornelia M. Ulrich,
John D. Potter,
PA Newcomb,
Robert E. Schoen,
Michael Hoffmeister,
Hermann Brenner,
Emily White,
Li Hsu,
P. Campbell
Publication year - 2015
Publication title -
international journal of epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.406
H-Index - 208
eISSN - 1464-3685
pISSN - 0300-5771
DOI - 10.1093/ije/dyv082
Subject(s) - mendelian randomization , medicine , confounding , odds ratio , confidence interval , demography , colorectal cancer , logistic regression , relative risk , oncology , cancer , genotype , genetics , genetic variants , biology , sociology , gene
For men and women, taller height is associated with increased risk of all cancers combined. For colorectal cancer (CRC), it is unclear whether the differential association of height by sex is real or is due to confounding or bias inherent in observational studies. We performed a Mendelian randomization study to examine the association between height and CRC risk.
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