Mendelian randomization studies: a review of the approaches used and the quality of reporting | Zendy

Anna G. C. Boef | Zendy; Olaf M. Dekkers | Zendy; Saskia le Cessie | Zendy

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Mendelian randomization studies: a review of the approaches used and the quality of reporting

Author(s) -

Anna G. C. Boef,

Olaf M. Dekkers,

Saskia le Cessie

Publication year - 2015

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyv071

Subject(s) - mendelian randomization , proxy (statistics) , statistical power , confounding , checklist , meta analysis , research design , medline , population , medicine , statistics , clinical study design , study heterogeneity , instrumental variable , sample size determination , econometrics , clinical trial , psychology , genotype , pathology , biology , cognitive psychology , mathematics , genetics , genetic variants , environmental health , biochemistry , gene

Mendelian randomization (MR) studies investigate the effect of genetic variation in levels of an exposure on an outcome, thereby using genetic variation as an instrumental variable (IV). We provide a meta-epidemiological overview of the methodological approaches used in MR studies, and evaluate the discussion of MR assumptions and reporting of statistical methods.

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