The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 | Zendy

Riccardo E. Marioni | Zendy; Sonia Shah | Zendy; Allan F. McRae | Zendy; Stuart J. Ritchie | Zendy; Graciela MuñizTerrera | Zendy; Sarah E. Harris | Zendy; Jude Gibson | Zendy; Paul Redmond | Zendy; Simon R. Cox | Zendy; Alison Pattie | Zendy; Janie Corley | Zendy; Adele M. Taylor | Zendy; Lee Murphy | Zendy; John M. Starr | Zendy; Steve Horvath | Zendy; Peter M. Visscher | Zendy; Naomi R. Wray | Zendy; Ian J. Deary | Zendy

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The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936

Author(s) -

Riccardo E. Marioni,

Sonia Shah,

Allan F. McRae,

Stuart J. Ritchie,

Graciela MuñizTerrera,

Sarah E. Harris,

Jude Gibson,

Paul Redmond,

Simon R. Cox,

Alison Pattie,

Janie Corley,

Adele M. Taylor,

Lee Murphy,

John M. Starr,

Steve Horvath,

Peter M. Visscher,

Naomi R. Wray,

Ian J. Deary

Publication year - 2015

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyu277

Subject(s) - epigenetics , physical fitness , cohort , dna methylation , cognition , epigenome , demography , grip strength , gerontology , biology , medicine , genetics , physiology , physical therapy , neuroscience , gene expression , sociology , gene

The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and four mortality-linked markers of physical and mental fitness: lung function, walking speed, grip strength and cognitive ability.

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