CD4+ T cell recovery during suppression of HIV replication: an international comparison of the immunological efficacy of antiretroviral therapy in North America, Asia and Africa | Zendy

Elvin Geng | Zendy; Torsten B. Neilands | Zendy; Rodolphe Thiébaut | Zendy; Mwebesa Bwana | Zendy; Denis Nash | Zendy; Richard D. Moore | Zendy; Robin Wood | Zendy; Djimon Marcel Zannou | Zendy; Keri N. Althoff | Zendy; Poh Lian Lim | Zendy; Jean B. Nachega | Zendy; Philippa Easterbrook | Zendy; Andrew Kambugu | Zendy; Francesca Little | Zendy; Gertrude Nakigozi | Zendy; Damalie Nakanjako | Zendy; Valerian Kiggundu | Zendy; Patrick Chung Ki Li | Zendy; David R. Bangsberg | Zendy; Matthew P. Fox | Zendy; Hans Prozesky | Zendy; Peter W. Hunt | Zendy; MaryAnn Davies | Zendy; Steven J. Reynolds | Zendy; Matthias Egger | Zendy; Constantin T. Yiannoutsos | Zendy; Eric Vittinghoff | Zendy; Steven G. Deeks | Zendy; Jeffrey N. Martin | Zendy

Open Access

CD4+ T cell recovery during suppression of HIV replication: an international comparison of the immunological efficacy of antiretroviral therapy in North America, Asia and Africa

Author(s) -

Elvin Geng,

Torsten B. Neilands,

Rodolphe Thiébaut,

Mwebesa Bwana,

Denis Nash,

Richard D. Moore,

Robin Wood,

Djimon Marcel Zannou,

Keri N. Althoff,

Poh Lian Lim,

Jean B. Nachega,

Philippa Easterbrook,

Andrew Kambugu,

Francesca Little,

Gertrude Nakigozi,

Damalie Nakanjako,

Valerian Kiggundu,

Patrick Chung Ki Li,

David R. Bangsberg,

Matthew P. Fox,

Hans Prozesky,

Peter W. Hunt,

MaryAnn Davies,

Steven J. Reynolds,

Matthias Egger,

Constantin T. Yiannoutsos,

Eric Vittinghoff,

Steven G. Deeks,

Jeffrey N. Martin

Publication year - 2015

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyu271

Subject(s) - efavirenz , nevirapine , medicine , confidence interval , antiretroviral therapy , immunology , viral load , demography , virology , human immunodeficiency virus (hiv) , sociology

Even among HIV-infected patients who fully suppress plasma HIV RNA replication on antiretroviral therapy, genetic (e.g. CCL3L1 copy number), viral (e.g. tropism) and environmental (e.g. chronic exposure to microbial antigens) factors influence CD4 recovery. These factors differ markedly around the world and therefore the expected CD4 recovery during HIV RNA suppression may differ globally.

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