Genetically predicted testosterone and electrocardiographic QT interval duration in Chinese: a Mendelian randomization analysis in the Guangzhou Biobank Cohort Study | Zendy

Jie Zhao | Zendy; Chao Jiang | Zendy; TH Lam | Zendy; Bin Liu | Zendy; Kar Keung Cheng | Zendy; Lin Xu | Zendy; Mary Jane Long | Zendy; Weizhen Zhang | Zendy; GM Leung | Zendy; C. Mary Schooling | Zendy

Open Access

Genetically predicted testosterone and electrocardiographic QT interval duration in Chinese: a Mendelian randomization analysis in the Guangzhou Biobank Cohort Study

Author(s) -

Jie Zhao,

Chao Jiang,

TH Lam,

Bin Liu,

Kar Keung Cheng,

Lin Xu,

Mary Jane Long,

Weizhen Zhang,

GM Leung,

C. Mary Schooling

Publication year - 2014

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyu241

Subject(s) - medicine , qt interval , testosterone (patch) , mendelian randomization , confounding , confidence interval , framingham heart study , heart rate , cardiology , endocrinology , framingham risk score , blood pressure , biology , genotype , genetics , disease , genetic variants , gene

QT interval prolongation, a predictor of cardiac arrhythmias, and elevated heart rate are associated with higher risk of cardiovascular mortality. Observationally testosterone is associated with shorter corrected QT interval and slower heart rate; however, the evidence is open to residual confounding and reverse causality. We examined the association of testosterone with electrocardiogram (ECG) parameters using a separate-sample instrumental variable (SSIV) estimator.

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