Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways | Zendy

Stephen Burgess | Zendy; Rhian Daniel | Zendy; Adam S. Butterworth | Zendy; Simon G. Thompson | Zendy

Open Access

Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways

Author(s) -

Stephen Burgess,

Rhian Daniel,

Adam S. Butterworth,

Simon G. Thompson

Publication year - 2014

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyu176

Subject(s) - mendelian randomization , instrumental variable , causal inference , confounding , mediation , outcome (game theory) , econometrics , marginal structural model , causality (physics) , estimator , covariate , indirect effect , statistics , psychology , biology , mathematics , genetics , genetic variants , genotype , physics , mathematical economics , quantum mechanics , gene , political science , law

Mendelian randomization uses genetic variants, assumed to be instrumental variables for a particular exposure, to estimate the causal effect of that exposure on an outcome. If the instrumental variable criteria are satisfied, the resulting estimator is consistent even in the presence of unmeasured confounding and reverse causation.

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