Causal associations of tobacco smoking with cardiovascular risk factors: a Mendelian randomization analysis of the HUNT Study in Norway | Zendy

Bjørn Olav Åsvold | Zendy; Johan Hå‌kon Bjø‌rngaard | Zendy; David Carslake | Zendy; Maiken E. Gabrielsen | Zendy; Frank Skorpen | Zendy; George Davey Smith | Zendy; Pål Romundstad | Zendy

Open Access

Causal associations of tobacco smoking with cardiovascular risk factors: a Mendelian randomization analysis of the HUNT Study in Norway

Author(s) -

Bjørn Olav Åsvold,

Johan Hå‌kon Bjø‌rngaard,

David Carslake,

Maiken E. Gabrielsen,

Frank Skorpen,

George Davey Smith,

Pål Romundstad

Publication year - 2014

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyu113

Subject(s) - mendelian randomization , medicine , blood pressure , body mass index , waist , waist–hip ratio , demography , obesity , risk factor , endocrinology , genetics , biology , genotype , genetic variants , sociology , gene

Tobacco smoking has been associated with cardiovascular risk factors including adverse serum lipid levels, central obesity and higher resting heart rate, but lower blood pressure and body mass index (BMI). We used a Mendelian randomization approach to study whether these associations may be causal. If smoking affects cardiovascular risk factors then rs1051730 T alleles, predictors of increased smoking quantity, should be associated with cardiovascular risk factors among smokers, but not among never smokers.

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