Arsenic metabolism efficiency has a causal role in arsenic toxicity: Mendelian randomization and gene-environment interaction | Zendy

Brandon L. Pierce | Zendy; Tong Lin | Zendy; Maria Argos | Zendy; Jianchang Gao | Zendy; Farzana Jasmine | Zendy; Roy Sk | Zendy; R. Paul-Brutus | Zendy; Ronald Rahaman | Zendy; M. Rakibuz-Zaman | Zendy; F. Parvez | Zendy; A. Ahmed | Zendy; I. Quasem | Zendy; S. K. Hore | Zendy; Shafiul Alam | Zendy; Mohammad Tariqul Islam | Zendy; J. Harjes | Zendy; G. Sarwar | Zendy; V. Slavkovich | Zendy; M. V. Gamble | Zendy; Yu Chen | Zendy; Mohammad Yunus | Zendy; Moazur Rahman | Zendy; J. A. Baron | Zendy; J. H. Graziano | Zendy; Habibul Ahsan | Zendy

Open Access

Arsenic metabolism efficiency has a causal role in arsenic toxicity: Mendelian randomization and gene-environment interaction

Author(s) -

Brandon L. Pierce,

Tong Lin,

Maria Argos,

Jianchang Gao,

Farzana Jasmine,

Roy Sk,

R. Paul-Brutus,

Ronald Rahaman,

M. Rakibuz-Zaman,

F. Parvez,

A. Ahmed,

I. Quasem,

S. K. Hore,

Shafiul Alam,

Mohammad Tariqul Islam,

J. Harjes,

G. Sarwar,

V. Slavkovich,

M. V. Gamble,

Yu Chen,

Mohammad Yunus,

Moazur Rahman,

J. A. Baron,

J. H. Graziano,

Habibul Ahsan

Publication year - 2013

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyt182

Subject(s) - mendelian randomization , arsenic , genetics , toxicity , arsenic toxicity , biology , gene , medicine , physiology , chemistry , genetic variants , genotype , organic chemistry

Arsenic exposure through drinking water is a serious global health issue. Observational studies suggest that individuals who metabolize arsenic efficiently are at lower risk for toxicities such as arsenical skin lesions. Using two single nucleotide polymorphisms(SNPs) in the 10q24.32 region (near AS3MT) that show independent associations with metabolism efficiency, Mendelian randomization can be used to assess whether the association between metabolism efficiency and skin lesions is likely to be causal.

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