Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: Systematic review and meta-analysis of 14 015 stroke cases and pooled analysis of primary biomarker data from up to 60 883 individuals | Zendy

Tauseef Khan | Zendy; Tina Shah | Zendy; David PrietoMerino | Zendy; Weili Zhang | Zendy; Jackie F. Price | Zendy; Gerald R. Fowkes | Zendy; Jackie A. Cooper | Zendy; Philippa J. Talmud | Zendy; Steve E. Humphries | Zendy; Johan Sundström | Zendy; Jaroslav A. Hubáček | Zendy; Shah Ebrahim | Zendy; Debbie A. Lawlor | Zendy; Yoav BenShlomo | Zendy; M.R. Abdollahi | Zendy; Arjen J. C. Slooter | Zendy; Zoltán Szolnoki | Zendy; Manjinder S. Sandhu | Zendy; Nicholas J. Wareham | Zendy; Ruth FrikkeSchmidt | Zendy; Anne TybjærgHansen | Zendy; Gerda G. Fillenbaum | Zendy; Bastiaan T. Heijmans | Zendy; Tomohiro Katsuya | Zendy; Grażyna Gromadzka | Zendy; Andrew B. Singleton | Zendy; Luigi Ferrucci | Zendy; John Hardy | Zendy; Bradford B. Worrall | Zendy; Stephen S. Rich | Zendy; Mar Matarín | Zendy; John C. Whittaker | Zendy; Tom R. Gaunt | Zendy; Peter H. Whincup | Zendy; Richard Morris | Zendy; John Deanfield | Zendy; Ann E. Donald | Zendy; George Davey Smith | Zendy; Mika Kivimäki | Zendy; Meena Kumari | Zendy; Liam Smeeth | Zendy; Kay-Tee Khaw | Zendy; Michael A. Nalls | Zendy; James F. Meschia | Zendy; Kai Sun | Zendy; Rutai Hui | Zendy; Ian N.M. Day | Zendy; Aroon D. Hingorani | Zendy; Juan P. Casas | Zendy

Open Access

Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: Systematic review and meta-analysis of 14 015 stroke cases and pooled analysis of primary biomarker data from up to 60 883 individuals

Author(s) -

Tauseef Khan,

Tina Shah,

David PrietoMerino,

Weili Zhang,

Jackie F. Price,

Gerald R. Fowkes,

Jackie A. Cooper,

Philippa J. Talmud,

Steve E. Humphries,

Johan Sundström,

Jaroslav A. Hubáček,

Shah Ebrahim,

Debbie A. Lawlor,

Yoav BenShlomo,

M.R. Abdollahi,

Arjen J. C. Slooter,

Zoltán Szolnoki,

Manjinder S. Sandhu,

Nicholas J. Wareham,

Ruth FrikkeSchmidt,

Anne TybjærgHansen,

Gerda G. Fillenbaum,

Bastiaan T. Heijmans,

Tomohiro Katsuya,

Grażyna Gromadzka,

Andrew B. Singleton,

Luigi Ferrucci,

John Hardy,

Bradford B. Worrall,

Stephen S. Rich,

Mar Matarín,

John C. Whittaker,

Tom R. Gaunt,

Peter H. Whincup,

Richard Morris,

John Deanfield,

Ann E. Donald,

George Davey Smith,

Mika Kivimäki,

Meena Kumari,

Liam Smeeth,

Kay-Tee Khaw,

Michael A. Nalls,

James F. Meschia,

Kai Sun,

Rutai Hui,

Ian N.M. Day,

Aroon D. Hingorani,

Juan P. Casas

Publication year - 2013

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyt034

Subject(s) - apolipoprotein e , medicine , genotype , stroke (engine) , odds ratio , meta analysis , biomarker , gastroenterology , disease , genetics , biology , gene , mechanical engineering , engineering

At the APOE gene, encoding apolipoprotein E, genotypes of the ε2/ε3/ε4 alleles associated with higher LDL-cholesterol (LDL-C) levels are also associated with higher coronary risk. However, the association of APOE genotype with other cardiovascular biomarkers and risk of ischaemic stroke is less clear. We evaluated the association of APOE genotype with risk of ischaemic stroke and assessed whether the observed effect was consistent with the effects of APOE genotype on LDL-C or other lipids and biomarkers of cardiovascular risk.

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