DNA methylation shows genome-wide association ofNFIX,RAPGEF2andMSRB3with gestational age at birth | Zendy

Hwa-Jin Lee | Zendy; Andrew E. Jaffe | Zendy; Jason I. Feinberg | Zendy; Rakel Tryggvadóttir | Zendy; Shan Brown | Zendy; Carolina Montaño | Zendy; Martin J. Aryee | Zendy; Rafael A. Irizarry | Zendy; Julie B. Herbstman | Zendy; Frank R. Witter | Zendy; Lynn R. Goldman | Zendy; Andrew P. Feinberg | Zendy; M. Daniele Fallin | Zendy

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DNA methylation shows genome-wide association ofNFIX,RAPGEF2andMSRB3with gestational age at birth

Author(s) -

Hwa-Jin Lee,

Andrew E. Jaffe,

Jason I. Feinberg,

Rakel Tryggvadóttir,

Shan Brown,

Carolina Montaño,

Martin J. Aryee,

Rafael A. Irizarry,

Julie B. Herbstman,

Frank R. Witter,

Lynn R. Goldman,

Andrew P. Feinberg,

M. Daniele Fallin

Publication year - 2012

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyr237

Subject(s) - genome wide association study , biology , genetics , dna methylation , medicine , genotype , single nucleotide polymorphism , gene , gene expression

Gestational age at birth strongly predicts neonatal, adolescent and adult morbidity and mortality through mostly unknown mechanisms. Identification of specific genes that are undergoing regulatory change prior to birth, such as through changes in DNA methylation, would increase our understanding of developmental changes occurring during the third trimester and consequences of pre-term birth (PTB).

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