Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype | Zendy

Reecha Sofat | Zendy; Juan P. Casas | Zendy; Andrew R. Webster | Zendy; Alan C. Bird | Zendy; Samantha Mann | Zendy; John R.W. Yates | Zendy; Anthony T. Moore | Zendy; Tiina Sepp | Zendy; Valentina Cipriani | Zendy; Catey Bunce | Zendy; Jane C. Khan | Zendy; Humma Shahid | Zendy; Anand Swaroop | Zendy; Gonçalo R. Abecasis | Zendy; Kari Branham | Zendy; Sepideh Zareparsi | Zendy; Arthur A. Bergen | Zendy; Caroline C. W. Klaver | Zendy; Dominique C. Baas | Zendy; Kang Zhang | Zendy; Yuhong Chen | Zendy; Daniel Gibbs | Zendy; Bernhard H. F. Weber | Zendy; Claudia N. Keilhauer | Zendy; Lars G. Fritsche | Zendy; Andrew Lotery | Zendy; Angela J. Cree | Zendy; Helen Griffiths | Zendy; Shomi S. Bhattacharya | Zendy; Li L Chen | Zendy; Sharon Jenkins | Zendy; Tünde Pető | Zendy; Mark Lathrop | Zendy; Thierry Léveillard | Zendy; Michael B. Gorin | Zendy; Daniel E. Weeks | Zendy; Maria Carolina Ortube | Zendy; Robert E. Ferrell | Zendy; Jóhanna Jakobsdóttir | Zendy; Yvette P. Conley | Zendy; Mati Rahu | Zendy; Johan H. Seland | Zendy; G. Soubrane | Zendy; Fotis Topouzis | Zendy; Jesús Vioqué | Zendy; Laura Tomazzoli | Zendy; Ian Young | Zendy; John C. Whittaker | Zendy; Usha Chakravarthy | Zendy; Paulus T.V.M. de Jong | Zendy; Liam Smeeth | Zendy; Astrid Fletcher | Zendy; Aroon D. Hingorani | Zendy

Open Access

Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype

Author(s) -

Reecha Sofat,

Juan P. Casas,

Andrew R. Webster,

Alan C. Bird,

Samantha Mann,

John R.W. Yates,

Anthony T. Moore,

Tiina Sepp,

Valentina Cipriani,

Catey Bunce,

Jane C. Khan,

Humma Shahid,

Anand Swaroop,

Gonçalo R. Abecasis,

Kari Branham,

Sepideh Zareparsi,

Arthur A. Bergen,

Caroline C. W. Klaver,

Dominique C. Baas,

Kang Zhang,

Yuhong Chen,

Daniel Gibbs,

Bernhard H. F. Weber,

Claudia N. Keilhauer,

Lars G. Fritsche,

Andrew Lotery,

Angela J. Cree,

Helen Griffiths,

Shomi S. Bhattacharya,

Li L Chen,

Sharon Jenkins,

Tünde Pető,

Mark Lathrop,

Thierry Léveillard,

Michael B. Gorin,

Daniel E. Weeks,

Maria Carolina Ortube,

Robert E. Ferrell,

Jóhanna Jakobsdóttir,

Yvette P. Conley,

Mati Rahu,

Johan H. Seland,

G. Soubrane,

Fotis Topouzis,

Jesús Vioqué,

Laura Tomazzoli,

Ian Young,

John C. Whittaker,

Usha Chakravarthy,

Paulus T.V.M. de Jong,

Liam Smeeth,

Astrid Fletcher,

Aroon D. Hingorani

Publication year - 2012

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyr204

Subject(s) - macular degeneration , factor h , complement (music) , complement factor i , disease , medicine , complement component 2 , complement system , risk factor , complement factor b , case control study , genetics , biology , immunology , gene , pathology , phenotype , antibody , ophthalmology , complementation

Variation in the complement factor H gene (CFH) is associated with risk of late age-related macular degeneration (AMD). Previous studies have been case-control studies in populations of European ancestry with little differentiation in AMD subtype, and insufficient power to confirm or refute effect modification by smoking.

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