Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction | Zendy

Rudolf P. Talens | Zendy; J. Wouter Jukema | Zendy; Stella Trompet | Zendy; Dennis Kremer | Zendy; Rudi G. J. Westendorp | Zendy; L. H. Lumey | Zendy; Naveed Sattar | Zendy; Hein Putter | Zendy; P. Eline Slagboom | Zendy; Bastiaan T. Heijmans | Zendy

Open Access

Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction

Author(s) -

Rudolf P. Talens,

J. Wouter Jukema,

Stella Trompet,

Dennis Kremer,

Rudi G. J. Westendorp,

L. H. Lumey,

Naveed Sattar,

Hein Putter,

P. Eline Slagboom,

Bastiaan T. Heijmans

Publication year - 2011

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyr153

Subject(s) - dna methylation , epigenetics , odds ratio , methylation , myocardial infarction , medicine , pregnancy , genetics , endocrinology , physiology , biology , dna , gene , gene expression

Human epidemiological studies suggest that small size at birth and food deprivation during gestation confer an excess risk of coronary heart diseases (CHD) in adulthood, frequently in a sex-specific manner. Prior epigenetic studies indicate that such prenatal conditions are marked by persistent and sometimes sex-specific changes in DNA methylation. Here, we have investigated the association between DNA methylation and myocardial infarction (MI) at six loci sensitive to prenatal nutrition, anticipating potential sex-specificity. Method Within the placebo group of the PROSPER trial on pravastatin and the risk of CHD, we compared all individuals who were event free at baseline and developed MI during 3 years' follow-up (n = 122) with a similar-sized control group. Methylation at IL10, LEP, ABCA1, IGF2, INS and GNASAS was measured in DNA extracted from leucocytes using mass spectrometry.

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