Apparent prevention of neural tube defects by periconceptional vitamin supplementation* | Zendy

R. W. Smithells | Zendy; S Sheppard | Zendy; C J Schorah | Zendy; Mary J. Seller | Zendy; N. C. Nevin | Zendy; R Harris | Zendy; Andrew Read | Zendy; Dorothy Fielding | Zendy

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Apparent prevention of neural tube defects by periconceptional vitamin supplementation*

Author(s) -

R. W. Smithells,

S Sheppard,

C J Schorah,

Mary J. Seller,

N. C. Nevin,

R Harris,

Andrew Read,

Dorothy Fielding

Publication year - 2011

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyr143

Subject(s) - neural tube , medicine , neural tube defect , obstetrics , gestation , pregnancy , vitamin , pediatrics , endocrinology , biology , embryo , genetics , microbiology and biotechnology

An earlier preliminary paper is expanded. Women who had given birth to one or more infants with a neural tube defect were recruited into a trial of periconceptional vitamin supplementation. Two hundred mothers attending five centres were fully supplemented (FS), 50 were partially supplemented (PS), and 300 were unsupplemented (US). Neural tube defect recurrences in the study pregnancies were 1(0.5%), in FS, none in PS, and 13 (4%) in US mothers. The difference in outcome between FS and US mothers is significant. The most likely explanation is that supplementation has prevented some neural tube defects, but further studies are needed.

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