Bias in the case-only design applied to studies of gene-environment and gene-gene interaction: a systematic review and meta-analysis | Zendy

Jessica Dennis | Zendy; S. Hawken | Zendy; Daniel Krewski | Zendy; Nick Birkett | Zendy; Gheorghe Militaru | Zendy; J Frei | Zendy; Gail McKeownEyssen | Zendy; Julian Little | Zendy

Open Access

Bias in the case-only design applied to studies of gene-environment and gene-gene interaction: a systematic review and meta-analysis

Author(s) -

Jessica Dennis,

S. Hawken,

Daniel Krewski,

Nick Birkett,

Gheorghe Militaru,

J Frei,

Gail McKeownEyssen,

Julian Little

Publication year - 2011

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyr088

Subject(s) - meta analysis , gene , meta regression , multiplicative function , genetics , gene interaction , value (mathematics) , computational biology , statistics , biology , medicine , mathematics , mathematical analysis

The case-only study, proposed as a design specifically for assessing departure from multiplicative gene-environment and gene-gene interactions, is of considerable potential value but there are concerns about its validity. The objective of this study was to evaluate the extent and sources of bias in the case-only design by means of a systematic review and meta-regression analysis.

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