Open AccessIn utero and intra-partum HIV-1 transmission and acute HIV-1 infection during pregnancy: using the BED capture enzyme-immunoassay as a surrogate marker for acute infection
Author(s) -
Edmore Marinda,
Lawrence H. Moulton,
Jean H. Humphrey,
John W. Hargrove,
Robert Ntozini,
Kuda Mutasa,
Jonathan Levin
Publication year - 2011
Publication title -
international journal of epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.406
H-Index - 208
eISSN - 1464-3685
pISSN - 0300-5771
DOI - 10.1093/ije/dyr055
Subject(s) - in utero , medicine , odds ratio , pregnancy , confidence interval , population , obstetrics , immunology , fetus , biology , genetics , environmental health
The BED assay was developed to estimate the proportion of recent HIV infections in a population. We used the BED assay as a proxy for acute infection to quantify the associated risk of mother-to-child-transmission (MTCT) during pregnancy and delivery. Design A total of 3773 HIV-1 sero-positive women were tested within 96 h of delivery using the BED assay, and CD4 cell count measurements were taken. Mothers were classified according to their likelihood of having recently seroconverted.