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Paracetamol and antibiotics in childhood and subsequent development of wheezing/asthma: association or causation?
Author(s) -
Franca Rusconi,
Luigi Gagliardi,
Claudia Galassi,
Francesco Forastiere,
Luigia Brunetti,
Stefania La Grutta,
Silvano Piffer,
Fiorella Talassi
Publication year - 2011
Publication title -
international journal of epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.406
H-Index - 208
eISSN - 1464-3685
pISSN - 0300-5771
DOI - 10.1093/ije/dyq263
Subject(s) - wheeze , medicine , odds ratio , asthma , confidence interval , pediatrics , respiratory tract infections , confounding , antibiotics , respiratory sounds , early childhood , respiratory system , psychology , developmental psychology , microbiology and biotechnology , biology
Several studies found an association between early administration of paracetamol and antibiotics and development of wheezing. This could be due to confounding: wheeze and asthmatic symptoms in early childhood are difficult to distinguish from respiratory tract infections that are widely treated with these drugs; in case of persistence of symptoms up to school age, this could explain the observed relationship.

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