Conventional and Mendelian randomization analyses suggest no association between lipoprotein(a) and early atherosclerosis: the Young Finns Study | Zendy

Mika Kivimäki | Zendy; Costan G. Magnussen | Zendy; Markus Juonala | Zendy; Mika Kähönen | Zendy; Johannes Kettunen | Zendy; Britt-Marie Loo | Zendy; Terho Lehtimäki | Zendy; Jorma Viikari | Zendy; Olli T. Raitakari | Zendy

Open Access

Conventional and Mendelian randomization analyses suggest no association between lipoprotein(a) and early atherosclerosis: the Young Finns Study

Author(s) -

Mika Kivimäki,

Costan G. Magnussen,

Markus Juonala,

Mika Kähönen,

Johannes Kettunen,

Britt-Marie Loo,

Terho Lehtimäki,

Jorma Viikari,

Olli T. Raitakari

Publication year - 2010

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyq205

Subject(s) - mendelian randomization , medicine , association (psychology) , genetics , mendelian inheritance , biology , psychology , gene , genotype , genetic variants , psychotherapist

Lipoprotein(a) [Lp(a)] is an established risk factor for coronary disease and stroke, but mechanisms underlying this association are unknown. We examined the association of Lp(a) with early atherosclerosis by using conventional epidemiologic analysis and a Mendelian randomization analysis. The latter utilized genetic variants that are associated with Lp(a) to estimate causal effect.

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