Efficacy of experimental treatments compared with standard treatments in non-inferiority trials: a meta-analysis of randomized controlled trials | Zendy

Darius Soonawala | Zendy; Rutger A. Middelburg | Zendy; Matthias Egger | Zendy; Jan P. Vandenbroucke | Zendy; Olaf M. Dekkers | Zendy

Open Access

Efficacy of experimental treatments compared with standard treatments in non-inferiority trials: a meta-analysis of randomized controlled trials

Author(s) -

Darius Soonawala,

Rutger A. Middelburg,

Matthias Egger,

Jan P. Vandenbroucke,

Olaf M. Dekkers

Publication year - 2010

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyq136

Subject(s) - medicine , relative risk , confidence interval , meta analysis , randomized controlled trial , clinical trial , placebo , pathology , alternative medicine

There is concern that non-inferiority trials might be deliberately designed to conceal that a new treatment is less effective than a standard treatment. In order to test this hypothesis we performed a meta-analysis of non-inferiority trials to assess the average effect of experimental treatments compared with standard treatments.

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