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Conflict of interest: None declared. References 1 Cornfield J, Haenszel W, Hammond EC, Lilienfeld AM, Shimkin MB, Wynder EL. Smoking and lung cancer: recent evidence and a discussion of some principles. J Natl Cancer Inst 1959;22:173–204. Reprinted Int J Epidemiol 2009;38:1175–91. 2 Cochran WG. The planning of observational studies of human populations (with discussion). J R Stat Soc A 1965;128:234–66.

Commentary: 'Smoking and lung cancer'--the embryogenesis of modern epidemiology