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Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals
Author(s) -
Esther H. Lips,
Valérie Gaborieau,
James McKay,
Amélie Chabrier,
Rayjean J. Hung,
Paolo Boffetta,
Mia Hashibe,
Давид Заридзе,
Neonilia SzeszeniaDabrowska,
Jolanta Lissowska,
Péter Rudnai,
Eleonóra Fabiánová,
Dana Mateș,
Vladimír Bencko,
Lenka Foretová,
Vladimí­r Janout,
John K. Field,
Triantafillos Liloglou,
George Xinarianos,
Esther M. John,
Geoffrey Liu,
Frank Skorpen,
Maiken Bratt Elvestad,
Kristian Hveem,
Lars J. Vatten,
EPIC Study,
Simone Benhamou,
Παγώνα Λάγιου,
Ivana Holcátová,
Franco Merletti,
Kristina Kjærheim,
Antonio Agudo,
Xavier Castellsagué,
Tatiana V. Macfarlane,
Luigi Barzan,
Cristina Canova,
Ray Lowry,
David I. Conway,
Ariana Znaor,
Claire M. Healy,
María Paula Curado,
Sérgio Koifman,
José ElufNeto,
Elena Matos,
Ana Menezes,
Leticia Fernández,
Andres Metspalu,
Simon Heath,
Mark Lathrop,
Paul Brennan
Publication year - 2009
Publication title -
international journal of epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.406
H-Index - 208
eISSN - 1464-3685
pISSN - 0300-5771
DOI - 10.1093/ije/dyp288
Subject(s) - odds ratio , minor allele frequency , confidence interval , single nucleotide polymorphism , genotype , medicine , lung cancer , allele , genome wide association study , genetics , gastroenterology , oncology , biology , gene
Genetic variants in 15q25 have been identified as potential risk markers for lung cancer (LC), but controversy exists as to whether this is a direct association, or whether the 15q variant is simply a proxy for increased exposure to tobacco carcinogens.

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