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geneity and proximity of homestead to roads in rural South Africa: an exploration using a geographical information system. Trop Med Int Health 2000;5:40–46. 44 Wawer MJ, Sewankambo NK, Berkley S et al. Incidence of HIV-1 infection in a rural region of Uganda. Br Med J 1994;308:171–73. 45 Ferguson AG, Morris CN. Mapping transactional sex on the Northern Corridor highway in Kenya. Health Place 2007;13:504–19. 46 Arroyo MA, Sateren WB, Serwadda D et al. Higher HIV-1 incidence and genetic complexity along main roads in Rakai District, Uganda. J Acquir Immune Defic Syndr 2006;43:440–45. 47 Williams BG, Gouws E. The epidemiology of human immunodeficiency virus in South Africa. Philos Trans R Soc Lond B Biol Sci 2001;356:1077–86. 48 Gould P, Wallace R. Spatial Structures and Scientific Paradoxes in the AIDS Pandemic. JSTOR, 1994. pp. 105–16. 49 Lurie MN, Williams BG, Zuma K et al. The impact of migration on HIV-1 transmission in South Africa: a study of migrant and nonmigrant men and their partners. Sex Transm Dis 2003;30:149–56. 50 Pickering H, Okongo M, Ojwiya A, Yirrell D, Whitworth J. Sexual networks in Uganda: mixing patterns between a trading town, its rural hinterland and a nearby fishing village. Int J STD AIDS 1997;8:495–500. 51 Aral SO. Behavioral aspects of sexually transmitted diseases: core groups and bridge populations. Sex Transm Dis 2000;27:327–28. 52 Moodley P, Connolly C, Sturm AW. Interrelationships among human immunodeficiency virus type 1 infection, bacterial vaginosis, trichomoniasis, and the presence of yeasts. J Infect Dis 2002;185:69–73. 53 Manhart LE, Holmes KK. Randomized controlled trials of individual-level, population-level, and multilevel interventions for preventing sexually transmitted infections: what has worked? J Infect Dis 2005;191 (Suppl 1):S7–S24. 54 Sumartojo E, Carey JW, Doll LS, Gayle H. Targeted and general population interventions for HIV prevention: towards a comprehensive approach. AIDS 1997;11:1201–9.

Commentary: Spatial clustering of HIV infection: providing clues for effective HIV prevention