Folate intake, markers of folate status and oral clefts: is the evidence converging? | Zendy

Candice Y. Johnson | Zendy; Julian Little | Zendy

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Folate intake, markers of folate status and oral clefts: is the evidence converging?

Author(s) -

Candice Y. Johnson,

Julian Little

Publication year - 2008

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyn098

Subject(s) - multivitamin , methylenetetrahydrofolate reductase , medicine , odds ratio , pregnancy , etiology , folic acid , physiology , vitamin , biology , genetics , genotype , gene

The ability of folic acid in the periconceptional period to prevent the occurrence of neural tube defects has stimulated tremendous interest in its effects on other health outcomes. Its possible effect on oral clefts has generated considerable debate. The purpose of this systematic review and meta-analysis was to assemble evidence on the role of folate in the aetiology of cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO).

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