High-throughput 1H NMR-based metabolic analysis of human serum and urine for large-scale epidemiological studies: validation study | Zendy

Richard H. Barton | Zendy; Jeremy K. Nicholson | Zendy; Paul Elliott | Zendy; Elaine Holmes | Zendy

Open Access

High-throughput 1H NMR-based metabolic analysis of human serum and urine for large-scale epidemiological studies: validation study

Author(s) -

Richard H. Barton,

Jeremy K. Nicholson,

Paul Elliott,

Elaine Holmes

Publication year - 2008

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dym284

Subject(s) - epidemiology , urine , scale (ratio) , throughput , medicine , computer science , physics , telecommunications , quantum mechanics , wireless

Metabolic profiling of biofluid specimens is an established method for investigating disease states in clinical studies but is only recently being applied to large-scale human population studies. As part of protocol development for the UK Biobank study, a (1)H nuclear magnetic resonance (NMR)-based metabonomic analysis of specimen storage effects and analytical reproducibility was carried out using urine and serum specimens from 40 volunteers.

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