SPP1 polymorphisms associated with HBV clearance and HCC occurrence | Zendy

H. D. Shin | Zendy; B. L. Park | Zendy; H. S. Cheong | Zendy; JungHwan Yoon | Zendy; Yoon Jun Kim | Zendy; H.-S. Lee | Zendy

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SPP1 polymorphisms associated with HBV clearance and HCC occurrence

Author(s) -

H. D. Shin,

B. L. Park,

H. S. Cheong,

JungHwan Yoon,

Yoon Jun Kim,

H.-S. Lee

Publication year - 2007

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dym093

Subject(s) - hepatocellular carcinoma , medicine , hepatitis b virus , genotype , taqman , population , hepatitis b , gastroenterology , haplotype , immunology , gene , biology , real time polymerase chain reaction , virus , genetics , environmental health

Secreted phosphoprotein-1 (SPP1) is a secreted arginine-glycine-aspartate (RGD)-containing phosphoprotein. SPP1 is overexpressed in metastatic hepatocellular carcinoma (HCC), and therefore could act as both a diagnostic marker and a potential therapeutic target for metastatic HCC. We investigated the genetic polymorphisms in SPP1 to determine whether it is a potential candidate gene for a host genetic study of hepatitis B virus (HBV) clearance and HCC occurrence.

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