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in the evolution of cancer cells during tumorigenesis, and suggest ways of controlling these processes through the manipulation of these shared, evolved mechanisms. As V&B have shown, thinking about cancer from an evolutionary point of view is rewarding and may offer new interpretations of epidemiological data. However, as Darwin explained in On the Origin of Species, changed conditions affect not only the selection but also the induction of heritable variations.

Commentary: Carcinogenesis as Darwinian evolution? Do the math!