Open AccessFibrinogen and coronary heart disease: test of causality by ‘Mendelian randomization’
Author(s) -
Bernard Keavney,
John Danesh,
Sarah Parish,
A. W. Palmer,
Sarah L. Clark,
Linda Youngman,
Marc Délepine,
Mark Lathrop,
Richard Peto,
Rory Collins
Publication year - 2006
Publication title -
international journal of epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.406
H-Index - 208
eISSN - 1464-3685
pISSN - 0300-5771
DOI - 10.1093/ije/dyl114
Subject(s) - fibrinogen , medicine , mendelian randomization , myocardial infarction , confounding , confidence interval , odds ratio , body mass index , gastroenterology , cardiology , genotype , endocrinology , biology , genetics , gene , genetic variants
Blood concentrations of fibrinogen have been associated with coronary heart disease risk in epidemiological studies, but it is uncertain whether this association is causal or reflects residual confounding by other risk factors. We investigated the relationship between the single nucleotide polymorphism at position -148 in the beta-fibrinogen gene promoter (beta - 148C/T), blood fibrinogen levels, and risk of myocardial infarction (MI) in sufficiently large numbers of coronary disease cases to reliably address this question.
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