Maternal prenatal exposure to nitrosatable drugs and childhood brain tumours | Zendy

Roberta McKeanCowdin | Zendy; Janice M. Pogoda | Zendy; William Lijinsky | Zendy; Elizabeth A. Holly | Zendy; Beth A. Mueller | Zendy; Susan PrestonMartin | Zendy

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Maternal prenatal exposure to nitrosatable drugs and childhood brain tumours

Author(s) -

Roberta McKeanCowdin,

Janice M. Pogoda,

William Lijinsky,

Elizabeth A. Holly,

Beth A. Mueller,

Susan PrestonMartin

Publication year - 2003

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyg050

Subject(s) - medicine , prenatal exposure , pregnancy , environmental health , gestation , biology , genetics

A compelling hypothesis was proposed that childhood brain tumours are associated with maternal exposure to N-nitroso compounds during the prenatal period. Many common drugs, such as antihistamines, aspirin, and antibiotics, are nitrosatable and depending upon the product, potentially carcinogenic. We hypothesized that maternal ingestion of certain subgroups of nitrosatable drug products during pregnancy increases the risk of brain tumour development in offspring.

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