Relation of plasma folate and methylenetetrahydrofolate reductase C677T polymorphism to colorectal adenomas | Zendy

Tomomi Marugame | Zendy; Emiko Tsuji | Zendy; Chikako Kiyohara | Zendy; Hiroyuki Eguchi | Zendy; Oda T | Zendy; Koichi Shinchi | Zendy; Suminori Kono | Zendy

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Relation of plasma folate and methylenetetrahydrofolate reductase C677T polymorphism to colorectal adenomas

Author(s) -

Tomomi Marugame,

Emiko Tsuji,

Chikako Kiyohara,

Hiroyuki Eguchi,

Oda T,

Koichi Shinchi,

Suminori Kono

Publication year - 2003

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyg004

Subject(s) - methylenetetrahydrofolate reductase , colorectal cancer , medicine , colorectal adenoma , reductase , endocrinology , metabolism , adenoma , gastroenterology , enzyme , oncology , genetics , biology , cancer , biochemistry , allele , gene

Folate intake may be related to decreased risk of colorectal cancer and adenomas. Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in folate metabolism. We examined the relation between plasma folate status and colorectal adenomas with reference to effect modification by the genetic polymorphism (C677T) of MTHFR.

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