Evaluating the direct effects of childhood adiposity on adult systemic metabolism: a multivariable Mendelian randomization analysis | Zendy

Tom G. Richardson | Zendy; Juha Mykkänen | Zendy; Katja Pahkala | Zendy; Mika AlaKorpela | Zendy; Joshua A. Bell | Zendy; Kurt Taylor | Zendy; Jorma Viikari | Zendy; Terho Lehtimäki | Zendy; Olli T. Raitakari | Zendy; George Davey Smith | Zendy

Open Access

Evaluating the direct effects of childhood adiposity on adult systemic metabolism: a multivariable Mendelian randomization analysis

Author(s) -

Tom G. Richardson,

Juha Mykkänen,

Katja Pahkala,

Mika AlaKorpela,

Joshua A. Bell,

Kurt Taylor,

Jorma Viikari,

Terho Lehtimäki,

Olli T. Raitakari,

George Davey Smith

Publication year - 2021

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyab051

Subject(s) - mendelian randomization , medicine , body mass index , childhood obesity , disease , endocrinology , physiology , biology , genetics , overweight , genetic variants , gene , genotype

Individuals who are obese in childhood have an elevated risk of disease in adulthood. However, whether childhood adiposity directly impacts intermediate markers of this risk, independently of adult adiposity, is unclear. In this study, we have simultaneously evaluated the effects of childhood and adulthood body size on 123 systemic molecular biomarkers representing multiple metabolic pathways.

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