Epigenome-wide association study of diet quality in the Women’s Health Initiative and TwinsUK cohort
Author(s) -
L. Whitney,
Eric A. Whitsel,
Ricardo Costeira,
Olatz M. Masachs,
Caroline I. Le Roy,
Jordana T. Bell,
Lisa R. Staimez,
Aryeh D. Stein,
Alicia K. Smith,
Steve Horvath,
Themistocles L. Assimes,
Simin Liu,
JoAnn E. Manson,
Aladdin H. Shadyab,
Yun Li,
Lifang Hou,
Parveen Bhatti,
Kristina M. Jordahl,
K.M. Venkat Narayan,
Karen N. Conneely
Publication year - 2020
Publication title -
international journal of epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.406
H-Index - 208
eISSN - 1464-3685
pISSN - 0300-5771
DOI - 10.1093/ije/dyaa215
Subject(s) - dna methylation , cohort , epigenome , epigenetics , medicine , physiology , cpg site , methylation , cohort study , body mass index , oncology , biology , endocrinology , genetics , gene , gene expression
Diet quality is a risk factor for chronic disease and mortality. Differential DNA methylation across the epigenome has been associated with chronic disease risk. Whether diet quality is associated with differential methylation is unknown. This study assessed whether diet quality was associated with differential DNA methylation measured across 445 548 loci in the Women's Health Initiative (WHI) and the TwinsUK cohort.
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