The genetics of signal transduction and the effect of smoking on intrauterine growth | Zendy

E. Bottini | Zendy; F. GloriaBottini | Zendy; Mauro La Torre | Zendy; N. Lucarini | Zendy

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The genetics of signal transduction and the effect of smoking on intrauterine growth

Author(s) -

E. Bottini,

F. GloriaBottini,

Mauro La Torre,

N. Lucarini

Publication year - 2001

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/30.2.400

Subject(s) - genotype , population , phosphatase , medicine , signal transduction , cytosol , biology , physiology , genetics , endocrinology , enzyme , environmental health , gene , biochemistry , phosphorylation

We have studied cytosolic low molecular weight phosphotyrosine phosphatase (cLMWPTP or ACP1) in 364 healthy puerperae from the population of Penne, in 155 diabetic puerperae from the population of Rome and in 349 consecutive normal newborn infants from the population of Rome. The data from these independent samples point to a protective role of maternal ACP1 genotypes with medium-high activity against intrauterine growth retardation caused by smoking.

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