Education and incident Alzheimer's disease: a biased association due to selective attrition and use of a two-step diagnostic procedure? | Zendy

Mirjam I. Geerlings | Zendy; Ben Schmand | Zendy; C. Jonker | Zendy; J. Lindeboom | Zendy; L.M. Bouter | Zendy

Open Access

Education and incident Alzheimer's disease: a biased association due to selective attrition and use of a two-step diagnostic procedure?

Author(s) -

Mirjam I. Geerlings,

Ben Schmand,

C. Jonker,

J. Lindeboom,

L.M. Bouter

Publication year - 1999

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/28.3.492

Subject(s) - attrition , association (psychology) , alzheimer's disease , medicine , disease , gerontology , psychology , dentistry , psychotherapist

It is still not clear whether a low level of education increases the risk of developing Alzheimer's disease (AD). Two common problems in cohort studies involving an elderly population and a two-step diagnostic procedure are the loss to follow-up without data on the presence of AD, and the fact that, in general, people with higher levels of education perform better on traditional cognitive tests, such as the Mini-Mental State Examination (MMSE). Both phenomena may lead to misclassification, resulting in a biased association between level of education and AD. This study investigated to what extent these selection mechanisms may influence this association.

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