Early two-dose measles vaccination schedule in Guinea-Bissau: good protection and coverage in infancy | Zendy

M.L. Garly | Zendy; Cesário Martins | Zendy; C. Bale | Zendy; F. da Costa | Zendy; F. Dias | Zendy; H. Whittle | Zendy; Peter Aaby | Zendy

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Early two-dose measles vaccination schedule in Guinea-Bissau: good protection and coverage in infancy

Author(s) -

M.L. Garly,

Cesário Martins,

C. Bale,

F. da Costa,

F. Dias,

H. Whittle,

Peter Aaby

Publication year - 1999

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/28.2.347

Subject(s) - measles , vaccination , medicine , pediatrics , new guinea , measles vaccine , environmental health , vaccination schedule , schedule , virology , immunology , immunization , history , antibody , computer science , ethnology , operating system

Previous studies from Africa have suggested that there is little benefit to be gained from early two-dose measles vaccination schedules. Two-dose schedules have been associated with no improvement in coverage due to immunization of the same individuals on both occasions, low return rate, high refusal rate, low vaccine efficacy, and fear of blunting of the antibody response. Because of the poor results achieved previously with two-dose measles vaccination schedules, we studied patterns of participation, reasons for non-participation, vaccination coverage and relative efficacy of a one-dose versus a two-dose schedule in connection with the implementation of an early two-dose trial in Guinea-Bissau.

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