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Common indices for the quantal assessment of treatment efficacy are reviewed. The absolute risk reduction is a practical index for public health considerations. Its reciprocal has been termed the 'Number Needed to Treat' (NNT), representing the health effort that must on average be expended to accomplish one tangible treatment target. We extend the NNT to evaluate outcome combinations of treatment benefits versus treatment harms.

international journal of epidemiology

‘Unqualified Success’ and ‘Unmitigated Failure’ Number-Needed-to-Treat-Related Concepts for Assessing Treatment Efficacy in the Presence of Treatment-Induced Adverse Events